Ader Isabelle
Dr Isabelle ADER is a researcher at INSERM within the RESTORE Institute dedicated to geroscience in Toulouse (UMR 1301-Inserm 5070, University of Toulouse). For many years, she was a member of the executive and scientific committee of INSPIRE, and she is currently a member of the management board of IHU HealthAge. Her research focuses on the impact of energy metabolism in maintaining cellular and tissue homeostasis, exploring both aging and pathologies such as cancer. She has conducted her research on various human cohorts, including MAPT, INSPIRE-T, and NHANES, seeking to establish links between energy metabolism and health trajectories. Her approach spans different scales, from the cell to the whole organism, and extends across different species. Her research, both translational and multidisciplinary, recently led to the discovery that a metabolic signature could predict cognitive decline more than 3 years before the appearance of any clinical signs. Furthermore, she contributed to a study published in 2023, where the use of artificial intelligence allowed distinguishing physiological age from chronological age based on metabolic variables. These recent works have been the subject of several patents, thus paving the way for future specific and personalized clinical monitoring for healthy aging and all age-related pathologies.
ANDRIEU Sandrine
BALARDY Laurent
Bischoff-Ferrari Heike
Prof. Heike A. Bischoff-Ferrari, DrPH is a certified in geriatric medicine, general internal medicine and rehabilitation. She holds a Master’s degree and doctoral degree from the Harvard School of Public Health in Boston and is Chair of Geriatrics and Aging Research at the University of Zurich since 2013. Prof. Bischoff-Ferrari is the coordinator of the largest European Healthy Longevity Trial and Biobank DO-HEALTH, and received a Lifetime Achievement Award for her research on Healthy Aging from the ICFSR in Boston in 2021. Since 2020 she has been a board member of the Harvard working group MINDING OUR FUTURE: Healthy Aging, Food, and Lifestyle, and since 2022 she has been a member of the WHO Clinical Consortium on Healthy Aging. Prof. Bischoff-Ferrari coordinated the collaborative concept and research proposal for the IHU HealthAge in partnership with Prof. Bruno Vellas and together with the public health, clinical and basic science teams in Toulouse from 2022 to 2023. Since 2024 Prof. Bischoff-Ferrari is the Director General IHU HealthAge.
Coley Nicola
Nicola Coley is an epidemiologist at Toulouse University Hospital, and member of the Aging team at the Centre for Epidemiology and Research in Population Health (CERPOP) at Toulouse 3 University and INSERM (the National Institute for Health and Medical Research). Her research activities focus on healthy aging, and particularly prevention trials. She has collaborated on various large prevention trials in France (GuidAge, MAPT) and Europe (HATICE, MIND-AD, PRODEMOS). Within the HealthAge IHU, she is leading the Open Science Hub, following on from her experience of coordinating data sharing activities within Toulouse University Hospital for Alzheimer’s and aging research since 2016. She has published more than 75 scientific articles and book chapters, and regularly serves as an expert evaluator for various international scientific journals and conferences, as well as for national and international grants.
De Souto Barreto Philipe
Philipe de Souto Barreto is Professor of Gerontology at Université Paul Sabatier Toulouse 3 (UT3), Director of the Institute on Aging (Toulouse University Hospital and UT3), member of the WHO Collaborating Center on Frailty, Clinical & Geroscience Research, and Geriatric Training, and leader of the IHU HealthAge Team “Lifestyle, intrinsic capacity and geroscience”. Professor Barreto’s main field of expertise is on physical activity and exercise during aging, having participated in the elaboration of international guidelines, task forces and consensus papers on this topic. More recently, he has been actively working on the area of Geroscience. Philipe has published more than 250 scientific articles, including in prestigious Journals such as JAMA Int Med or BMJ. Professor Barreto serves as Editor-in-Chief of the Journal of Nutrition, Health & Aging since December 2021.
CONTI Bruno
Dray Cédric
Cédric Dray PhD. is an Associate Professor at the Paul Sabatier University Toulouse III France, specialized in Pharmacology and Physiology. Dr Dray obtained his PhD in 2010 by demonstrating the role of apelin on metabolic diseases. Since 2021, Dr Dray is the leader of a research team at the RESTORE Institute (INSERM/CNRS/EFS/UPS) which is dedicated to the study of aging mechanisms and gerosciences throught a transdisciplinary innovative approach. In this context, metabolism exibits a crucial role and allows to propose therapeutical and preventive strategies Since 2019, Drs Dray and Pradère co-lead the Nothobranchuis Killifish plateform within the INSPIRE and HealthAge projects.
Fazilleau Nicolas
Nicolas Fazilleau, PhD in Immunology in 2004, is a Research Director at Inserm (French National Institute of Health and Medical Research) and heads the Research Unit ‘Toulouse Institute for Infectious and Inflammatory Diseases (Infinity)’ on the Purpan hospital campus. He is a cellular and molecular immunologist with over two decades of experience in the academic field, having worked both in the United States (The Scripps Research Institute, California) and in France (Institut Pasteur Paris and Infinity). He possesses an in-depth understanding of T lymphocyte biology in rodent models and in humans. His research activity is primarily focused on the mechanisms regulating antibody responses during vaccination, aging, and chronic dysimmune pathologies.
GOULAO Catarina
Guyonnet Sophie
Sophie Guyonnet is a Biologist (PhD, HDR) specialized in Nutrition and Aging Research, Associate Professor at the IHU HealthAge, Gérontopôle/Toulouse University Hospital Department of Geriatric Medicine, University Toulouse III, CERPOP (Center for Epidemiology and Research in Population Health, UMR1295 INSERM (Aging Team). She is Responsible for the development of the Gerontopole Cinical Research programs, including design and execution of trials, regulatory procedures, budget, timelines, and communicating with key internal and external stakeholders. It field of expertise includes National and European coordination of large multicentric cohort of patients with Alzheimer Disease (REAL.FR study, PLASA study); National coordination of large multicentric preventive trials in the field of neurodegenerative diseases (MAPT, MAPT PLUS, NOLAN); Coordination of human biobanks (MAPT, NOLAN, INSPIRE-T); Nutritional factors, cognition and prevention of neurodegenerative diseases; Nutritional factors and prevention of intrinsic capacity decline; Multidomain approach. Since 2019, She is in charge of the management of the Inspire Bio-resource Research Platform for Healthy Aging; the main objective of this platform is to build a comprehensive research platform gathering biological, clinical (including imaging) and digital resources that will be explored to identify robust (set of) markers of aging, age-related diseases and intrinsic capacity evolution. One of the most challenge of the Inspire Platform is the implementation of a Human Translational Research cohort (INSPIRE-T cohort) and animal cohorts in mirror. Since 2024, she is the program director of the IHU HealthAge on healthy longevity, prevention and gerosciences.
Lairez Olivier
Olivier Lairez, MD, PhD, est Professeur des Universités – Praticien Hospitalier à l’Université Toulouse 3 – Paul Sabatier. Il est cardiologue et médecin nucléaire, et exerce son activité clinique au centre hospitalier universitaire de Toulouse. Après deux ans au sein de l’Institut d’imagerie translationnelle et moléculaire de l’Icahn School of Medicine at Mount Sinai, à New York, il a mis en place le centre d’imagerie cardiaque du centre hospitalier universitaire de Toulouse. Ses recherches portent sur l’exploration des cardiomyopathies et du vieillissement myocardique menant à l’insuffisance cardiaque. Il s’intéresse particulièrement à l’amylose cardiaque à transthyrétine sauvage comme modèle du vieillissement cardiaque. En 2021, il a obtenu un master en économie de la santé et management dans les sciences cardiovasculaires à la London School of Economics, à Londres, puis a pris la direction de la recherche et de l’innovation du centre hospitalier universitaire de Toulouse pendant 3 ans. Il est actuellement vice-président délégué innovation et partenariats de l’Université Toulouse 3 – Paul Sabatier et dirige la recherche translationnelle à l’institut hospitalo-universitaire HealthAge.
Langin Dominique
Prof. Dominique Langin, DVM PhD, is director of the Institute of Metabolic and Cardiovascular Diseases (I2MC, Inserm University of Toulouse, France). Following doctoral studies in France, he did a post-doctoral internship at the University of Lund in Sweden and, back to France, embarked on a scientific career at CNRS and Inserm. He now holds a professor position at the University Toulouse III – Paul Sabatier and at the University Hospital of Toulouse. He has coordinated several national and European research projects and obtained a Synergy grant from the European Research Council (ERC) in 2020. He received the Friedrich Wassermann Life Time Achievement Award from the European Association for the Study of Obesity in 2011 and the Labbé Prize from the Academy of Sciences in 2019. In 2014 and 2021, he was appointed senior member of the Institut Universitaire de France. He has devoted his scientific career to the study of the biology of adipose tissue, obesity and diabetes, with a focus on fatty acid metabolism. He has contributed to about 260 original and 80 review articles (h-index 80 WoS). In IHU HealthAge, Prof. Langin coordinates the interface with the 14 research teams and 6 technological facilities of I2MC and develops a program on the importance of adipose distribution in aging-associated metabolic abnormalities.
LOZACHMEUR Jean-Marie
Martinez Laurent
Laurent Martinez is a research director at Inserm and currently leads the LiMitAging team at I2MC. He began his career with a major publication on the ectopic localization of mitochondrial ATP synthase (Nature. 2003;421(6918):75-9). He has also collaborated with Professor Alan Tall at Columbia University (New York City, USA) and Nobel laureate in chemistry, John E. Walker, at the University of Cambridge, UK, between 2002 and 2005.Laurent Martinez is a member of several scientific councils, including the scientific commission of Inserm, the scientific council of the University of Toulouse III, and the executive committee of the Hospital-University Institute HealthAge dedicated to healthy aging. Additionally, he contributes to the work of the Geroscience Translational Clinical Task Force (USA) and serves as associate editor for the journal Atherosclerosis.His team, specializing in research on metabolic and cardiovascular pathologies and healthy aging, has earned Laurent Martinez several distinctions, including the Lavoisier Prize (2001), EMBO (2004), and Inserm Avenir (2006) awards. With his team, he recently demonstrated that targeting the activity of the adipocyte receptor P2Y13 is a promising strategy against age-related metabolic disorders, and he was the first to identify the circulating form of the mitochondrial protein IF1 as a biomarker in the context of cardiometabolic diseases and aging.
Parini Angelo
Angelo PARINI is a cardiologist, Emeritus Professor at the Faculty of Health of Toulouse and a hospital practitioner at the University Hospital of Toulouse. Between 2007 and 2020 he headed the Institute of Metabolic and Cardiovascular Diseases of Toulouse. He is a member of numerous national and international evaluation committees. His research activity focuses mainly on the molecular mechanisms responsible for aging and heart failure. Since 2019, he has been coordinating the implementation and characterization of translational mouse cohorts as part of the INSPIRE project and the HealthAGE IHU.
Rolland Yves
Yves ROLLAND (MD, PhD) is Professor of Internal Medicine and Geriatrics at the Gerontopôle of Toulouse (France) and he is the Clinical Research Director of the IHU HealthAge dedicated to Prevention and Geroscience. He has a postgraduate diploma in Rheumatology and in Sports Medicine. He is member of the CERPO Team, UMR1295 (INSERM) at the University Toulouse III Paul Sabatier (MAINTAIN – MAintain Functions and INTrinsec capacities with Aging: Preventive and Personalized INterventional Research). He is the Editor in chief of the Journal of Nursing Home Research (JNHR). He is the author of more than 400 articles indexed Pubmed including around 80 articles related to Nursing Home care.
Rouch Laure
Dr. Laure Rouch, PharmD, PhD, HDR is an Epidemiologist and Associate Professor at IHU HealthAge, Toulouse, France, specifically CERPOP (Center for Epidemiology and Research in Population Health, UMR 1295 INSERM University Toulouse III, Aging Team, Maintain Functions Intrinsic Capacities with Aging Preventive Personalized Interventional Research). Beyond her primary focus on research, she also serves in the Department of Geriatric Medicine, Toulouse University Hospital (clinical practice) and Department of Clinical Pharmacy, Toulouse Health University (teaching practice) as a Clinical Pharmacist (PharmD). Over the last ten years, she has conducted research on the epidemiology of brain health, particularly on the identification of cardiovascular risk factors and disease for cognitive impairment and dementia over the life course, with the goal of uncovering opportunities for prevention. She recently extended her research interest to Aging Biology, Geroscience and Healthy Longevity. Her current translational research work includes understanding the molecular basis, especially using epigenomics, metabolomics, transcriptomics and proteomics data, that lead to physiological and functional decline during aging. Her postdoctoral training at the University of California, San Francisco was the foundation for sustained international partnerships, reflecting her proficiency in leading cross-border research collaborations.
Soto-Martin Maria Eugénia
Professor in Geriatrics, Maria Eugenia Soto Martin, MD, PhD, is head of the Clinical & Research Alzheimer disease Center of the Toulous university hospital. She is a member of the Research Aging Team, CERPOP (UMR 1295), Axe MAINTAIN (MAintain Functions and INTrinsec capacities with Aging: Preventive and Personalized INterventional Research. Since 2012 he is the medical head of the Aging and Disability Prevention Team of the Gerontopole, a WHO-collaborating centre for Frailty, Clinical Research and Geriatric Training. Currently, she leads with Prof Bruno Vellas the implementation of ICOPE WHO program in the region of Occitanie in France. Recently she has been missioned by the Health, Labor and Solidarity French ministry as a « qualified person” in order to elaborate the national governmental strategy for neurodegenerative diseases for 2024-2028.Currently she is member of the Management Board of IHU HealthAge.
Vellas Bruno
Bruno Vellas is the Founder of the Institut Hospitalier Universitaire (IHU) HealthAge in healthy aging, prevention and geroscience, Toulouse, France and the chair of the Gérontopôle & Department of Geriatric Internal Medicine at the Toulouse University Hospital and is member of INSERM UMR 1295. He studied medicine in Toulouse and received the degree of Doctor of Medicine in 1987 and a PhD in Pysiopathology in 1990. He had a doctoral training in nutrition and aging at the University of New Mexico, USA, Clinical Nutrition Lab, School of Medicine from 1987 to 1988. His main interests are: clinical trials in Alzheimer’s disease, frailty and geroscience which have been supported by several national, European and international research grants. He is the founder of the Gérontopôle to develop innovation and research for older adults.
He is the author and co-author of more than 500 publications in peer review journals since 1987, Index H: over 130. He serves as editor, editorial committee member and reviewer of several major journals. He is adjunct professor at the Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA and is member of the Scientific Advisory Board of several major scientific institutions in France, EU, Japan and the US. Since 2016, he is titular member of the French National Academy of Medicine, Officier de la Légion d’Honneur, and was recipient of the Palmes Académiques in 2016. He is the past president of the IAGG (International Association of Gerontology and Geriatrics), a NGO with a seat at the United Nations, and the founder of the EADC (European Alzheimer’s Disease Consortium), the CTAD (Clinical Trial in Alzheimer’s Disease conference) and the ICFSR (International Conference for Frailty and Sarcopenia Research). He is the chair of the WHO Collaborating Center for Frailty, Clinical Research and Geriatric Training since September 2017. In addition, Bruno VELLAS was invited to participate in the Evaluation Committee of WHO’s Global Strategy on Ageing and Health 2016-2020.
He is also Member of WHO’s Advisory Committee for Health Research and Innovation (ACHRI Lastly, Bruno VELLAS is President of the Scientific Committee of the French National “Great Age” Scheme (Plan National “Grand Age”) 2019, and Coordinator of the INSPIRE program in the field of Gerosciences.
