{"id":506,"date":"2020-04-10T15:35:32","date_gmt":"2020-04-10T13:35:32","guid":{"rendered":"https:\/\/inspire.chu-toulouse.fr\/?page_id=506"},"modified":"2020-05-27T12:47:22","modified_gmt":"2020-05-27T10:47:22","slug":"senescence","status":"publish","type":"page","link":"https:\/\/ihuhealthage.fr\/fr\/senescence\/","title":{"rendered":"S\u00e9nescence"},"content":{"rendered":"<h2>D\u00e9terminer le r\u00f4le des d\u00e9r\u00e9gulations des \u00e9l\u00e9ments transposables des cellules T dans le vieillissement et l&rsquo;immunos\u00e9nescence<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1077 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"146\" height=\"73\" \/>L&rsquo;hypoth\u00e8se est que les d\u00e9r\u00e9gulations des voies \u00e9pig\u00e9n\u00e9tiques observ\u00e9es chez les personnes \u00e2g\u00e9es perturbent l\u2019activit\u00e9 cis-r\u00e9gulatrice des \u00e9l\u00e9ments transposables dans les cellules T, et ont donc un r\u00f4le causal dans l\u2019immunos\u00e9nescence. Ce travail devrait permettre l\u2019identification de nouvelles cibles mol\u00e9culaires qui pourraient \u00eatre manipul\u00e9es pour r\u00e9tablir la r\u00e9ponse immunitaire protectrice chez les personnes \u00e2g\u00e9es.<\/p>\n<p><b><i>\u00a0<\/i><\/b><\/p>\n<h2>R\u00f4le de la prominine 2 comme biomarqueur du vieillissement de la cellule cardiaque<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1077 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"146\" height=\"73\" \/>En effectuant des exp\u00e9riences de s\u00e9quen\u00e7age dans les cardiomyocytes, nous avons trouv\u00e9 une forte corr\u00e9lation entre l\u2019expression de la Prom 2 et le vieillissement dans les oreillettes cardiaques des patients.\u00a0Prom 2 peut \u00eatre trouv\u00e9e dans les exosomes.\u00a0Nous quantifierons la Prom2 libre et associ\u00e9e \u00e0 l\u2019exosome dans le plasma des sujets des cohortes INSPIRE humaines et animales.\u00a0Notre objectif sera de d\u00e9terminer le r\u00f4le potentiel de Prom2 en tant que biomarqueur du vieillissement\/de l\u2019insuffisance cardiaque acc\u00e9l\u00e9r\u00e9e.<\/p>\n<p><span class=\"Apple-converted-space\">Responsable de ce projet de recherche: <\/span><span class=\"Apple-converted-space\">Jeanne Mialet &#8211; Perez jeanne.perez@inserm.fr<\/span><b><i><span class=\"Apple-converted-space\"><br \/>\n<\/span><br \/>\n<\/i><\/b><\/p>\n<h2>Effets de l\u2019alimentation limit\u00e9e dans le temps (TRF) et d\u2019agents s\u00e9nolytiques sur le d\u00e9clenchement de la fragilit\u00e9<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1077 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"146\" height=\"73\" \/>L\u2019objectif g\u00e9n\u00e9ral de ce projet est de d\u00e9terminer si la TRF pourrait pr\u00e9venir ou ralentir par rapport aux agents s\u00e9nolytiques, chez les hommes et les femmes.\u00a0La comparaison entre le TRF et le traitement s\u00e9nolytique permettra d\u2019\u00e9valuer leurs effets respectifs et d\u2019identifier les compl\u00e9mentarit\u00e9s potentielles, qui pourraient \u00eatre pertinentes chez l\u2019homme. L\u2019accumulation de cellules s\u00e9nescentes et l\u2019apparition de troubles multi-organes li\u00e9s \u00e0 l\u2019\u00e2ge.<\/p>\n<p><span class=\"Apple-converted-space\">Responsable de ce projet de recherche: <\/span>Ana\u00efs Briot &#8211; anais.briot@inserm.fr<\/p>\n","protected":false},"excerpt":{"rendered":"<p>D\u00e9terminer le r\u00f4le des d\u00e9r\u00e9gulations des \u00e9l\u00e9ments transposables des cellules T dans le vieillissement et l&rsquo;immunos\u00e9nescence L&rsquo;hypoth\u00e8se est que les d\u00e9r\u00e9gulations des voies \u00e9pig\u00e9n\u00e9tiques observ\u00e9es chez les personnes \u00e2g\u00e9es perturbent l\u2019activit\u00e9 cis-r\u00e9gulatrice des \u00e9l\u00e9ments transposables dans les cellules T, et ont donc un r\u00f4le causal dans l\u2019immunos\u00e9nescence. Ce travail devrait permettre l\u2019identification de nouvelles cibles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-506","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>S\u00e9nescence - IHU Healthage<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ihuhealthage.fr\/fr\/senescence\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"S\u00e9nescence - IHU Healthage\" \/>\n<meta property=\"og:description\" content=\"D\u00e9terminer le r\u00f4le des d\u00e9r\u00e9gulations des \u00e9l\u00e9ments transposables des cellules T dans le vieillissement et l&rsquo;immunos\u00e9nescence L&rsquo;hypoth\u00e8se est que les d\u00e9r\u00e9gulations des voies \u00e9pig\u00e9n\u00e9tiques observ\u00e9es chez les personnes \u00e2g\u00e9es perturbent l\u2019activit\u00e9 cis-r\u00e9gulatrice des \u00e9l\u00e9ments transposables dans les cellules T, et ont donc un r\u00f4le causal dans l\u2019immunos\u00e9nescence. Ce travail devrait permettre l\u2019identification de nouvelles cibles [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ihuhealthage.fr\/fr\/senescence\/\" \/>\n<meta property=\"og:site_name\" content=\"INSPIRE\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-27T10:47:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/\",\"url\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/\",\"name\":\"S\u00e9nescence - IHU Healthage\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ihuhealthage.fr\\\/wp-content\\\/uploads\\\/2020\\\/05\\\/unnamed-2.png\",\"datePublished\":\"2020-04-10T13:35:32+00:00\",\"dateModified\":\"2020-05-27T10:47:22+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ihuhealthage.fr\\\/wp-content\\\/uploads\\\/2020\\\/05\\\/unnamed-2.png\",\"contentUrl\":\"https:\\\/\\\/ihuhealthage.fr\\\/wp-content\\\/uploads\\\/2020\\\/05\\\/unnamed-2.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/senescence\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"S\u00e9nescence\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/\",\"name\":\"IHU Healthage\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ihuhealthage.fr\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"S\u00e9nescence - IHU Healthage","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ihuhealthage.fr\/fr\/senescence\/","og_locale":"fr_FR","og_type":"article","og_title":"S\u00e9nescence - IHU Healthage","og_description":"D\u00e9terminer le r\u00f4le des d\u00e9r\u00e9gulations des \u00e9l\u00e9ments transposables des cellules T dans le vieillissement et l&rsquo;immunos\u00e9nescence L&rsquo;hypoth\u00e8se est que les d\u00e9r\u00e9gulations des voies \u00e9pig\u00e9n\u00e9tiques observ\u00e9es chez les personnes \u00e2g\u00e9es perturbent l\u2019activit\u00e9 cis-r\u00e9gulatrice des \u00e9l\u00e9ments transposables dans les cellules T, et ont donc un r\u00f4le causal dans l\u2019immunos\u00e9nescence. Ce travail devrait permettre l\u2019identification de nouvelles cibles [&hellip;]","og_url":"https:\/\/ihuhealthage.fr\/fr\/senescence\/","og_site_name":"INSPIRE","article_modified_time":"2020-05-27T10:47:22+00:00","og_image":[{"url":"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/","url":"https:\/\/ihuhealthage.fr\/fr\/senescence\/","name":"S\u00e9nescence - IHU Healthage","isPartOf":{"@id":"https:\/\/ihuhealthage.fr\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/#primaryimage"},"image":{"@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/#primaryimage"},"thumbnailUrl":"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png","datePublished":"2020-04-10T13:35:32+00:00","dateModified":"2020-05-27T10:47:22+00:00","breadcrumb":{"@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ihuhealthage.fr\/fr\/senescence\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/#primaryimage","url":"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png","contentUrl":"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png"},{"@type":"BreadcrumbList","@id":"https:\/\/ihuhealthage.fr\/fr\/senescence\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/ihuhealthage.fr\/fr\/"},{"@type":"ListItem","position":2,"name":"S\u00e9nescence"}]},{"@type":"WebSite","@id":"https:\/\/ihuhealthage.fr\/fr\/#website","url":"https:\/\/ihuhealthage.fr\/fr\/","name":"IHU Healthage","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ihuhealthage.fr\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/pages\/506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/comments?post=506"}],"version-history":[{"count":8,"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/pages\/506\/revisions"}],"predecessor-version":[{"id":1498,"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/pages\/506\/revisions\/1498"}],"wp:attachment":[{"href":"https:\/\/ihuhealthage.fr\/fr\/wp-json\/wp\/v2\/media?parent=506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}