{"id":647,"date":"2020-04-27T15:02:31","date_gmt":"2020-04-27T13:02:31","guid":{"rendered":"https:\/\/inspire.chu-toulouse.fr\/?page_id=647"},"modified":"2020-05-27T13:02:25","modified_gmt":"2020-05-27T11:02:25","slug":"senescence","status":"publish","type":"page","link":"https:\/\/ihuhealthage.fr\/en\/senescence\/","title":{"rendered":"Senescence"},"content":{"rendered":"<h2>A role for transposable elements deregulation in T cell ageing and immunosenescence?<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1078 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"134\" height=\"67\" \/>We emit the hypothesis that the deregulations of the epigenetic pathways observed in elderly individuals perturb transposable elements<span class=\"Apple-converted-space\">\u00a0 <\/span>cis-regulatory activity in T cell, and have therefore a causal role in immunosenescence. Our work should allow the identification of new molecular targets which could be manipulated to restore protective immune response in the elderly.<\/p>\n<h2>Role of prominin 2 as biomarker of cardiac aging<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1078 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"134\" height=\"67\" \/>Recently, performing RNA sequencing experiments in cardiomyocytes, we found a strong correlation between Prom 2 expression and aging in cardiac atria of patients. Prom 2 can be found in exosomes. In the framework of the INSPIRE project, we will quantify free and exosome\u2212associated Prom2 in plasma from human and animal cohorts. Our goal will be to determine the potential role of Prom2 as biomarker of cardiac accelerated aging\/failure.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>Principal investigator of this study: Jeanne Mialet-Perez \u2013 jeanne.perez@inserm.fr<\/p>\n<h2>Effects of Time Restricted Feeding and senolytics on the onset of frailty<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1078 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"134\" height=\"67\" \/>The overall objective of this project is to determine whether TRF could prevent or slow down the accumulation of senescent cells and the onset of age-related multi-organ disorders, compared to senolytic agents, in both males and females. The comparison between TRF and senolytic treatment will allow to assess their respective effects and to identify potential complementarities, which could be relevant to humans.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><span class=\"Apple-converted-space\">Responsable de ce projet de recherche:\u00a0<\/span>Ana\u00efs Briot \u2013 anais.briot@inserm.fr<\/p>\n<h2>Prevention of multi-organ premature aging through mitochondria-targeted strategies<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1078 alignleft\" src=\"https:\/\/ihuhealthage.fr\/wp-content\/uploads\/2020\/05\/unnamed-2.png\" alt=\"\" width=\"134\" height=\"67\" \/>In this project, the prospective benefits of mitochondria-targeted nutritional strategies will be assessed to prevent multi-organ premature aging.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A role for transposable elements deregulation in T cell ageing and immunosenescence? We emit the hypothesis that the deregulations of the epigenetic pathways observed in elderly individuals perturb transposable elements\u00a0 cis-regulatory activity in T cell, and have therefore a causal role in immunosenescence. Our work should allow the identification of new molecular targets which could [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-647","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Senescence - IHU Healthage<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ihuhealthage.fr\/en\/senescence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Senescence - IHU Healthage\" \/>\n<meta property=\"og:description\" content=\"A role for transposable elements deregulation in T cell ageing and immunosenescence? We emit the hypothesis that the deregulations of the epigenetic pathways observed in elderly individuals perturb transposable elements\u00a0 cis-regulatory activity in T cell, and have therefore a causal role in immunosenescence. 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